CHROMOSOME ABERRATIONS INDUCED BY X-RAYS

Analysis of the chromosome aberrations induced by x-rays in somatic cells of Drosophila melanogaster.

A technique has been perfected for enabling good microscope preparations to be obtained from the larval ganglia of Drosophila melanogaster. This system was then tested with X-rays and an extensive series of data was obtained on the chromosome aberrations induced in the various stages of the cell cycle.-The analysis of the results obtained offers the following points of interest: (1) There exist...

The Effect of Temperature on X-Ray Induced Chromosome Aberrations.

Chromosome aberrations in persons accidentally exposed to 192Ir gamma-rays.

Chromosome examinations were made both in cultured peripheral lymphocytes and in freshly aspirated bone marrow cells of 6 persons accidentally exposed to gamma rays from an 192Ir. Samplings of peripheral blood for the chromosome analysis were repeated mostly at weekly in tervals during the hospitalization beginning on 10-11 days after the initial exposure, and at more prolonged intervals after ...

Quantitative analysis of radiation-induced chromosome aberrations.

We review chromosome aberration modeling and its applications, especially to biodosimetry and to characterizing chromosome geometry. Standard results on aberration formation pathways, randomness, dose-response, proximity effects, transmissibility, kinetics, and relations to other radiobiological endpoints are summarized. We also outline recent work on graph-theoretical descriptions of aberratio...

Quantification of High LET Induced Chromosome Aberrations

The classical cytogenetic assay relies on the scoring of chromosomal damage in cells at metaphase. According to the standard protocol the analysis is confined to cells at the 1st post-irradiation mitosis collected at one, early sampling time. For sparsely ionizing radiation this protocol allows a reasonable estimate of chromosomal damage, because in all commonly used cell system no or only a sl...